Lost memory: what's new in the science of Alzheimer's disease and how it relates to neuroplasticity, biochemistry, biophysics and genetics


  • Henrique Peixoto Colégio Arena
  • Romulo Rodrigues
  • Samuel Nunes




Biochemistry. Neuroplasticity. Genetics. Alzheimer’s Disease. Biophysics


During a long time, scientists believed that the brain was immutable, which means that, after its development in childhood, the brain would stay the same during the entire life of the human being, which would only change once it started to deteriorate. With the revolutionary discovery that the brain can change itself and adapt under certain circumstances cause a complete change in the way that neuroscientists treated and searched neurodegenerative diseases, especially Alzheimer. This article’s purpose is to bring a greater comprehension of everything that science knows and doesn’t, about Alzheimer’s disease, bringing its epidemiology, risk factors, main causes, the best treatments e list all of this with neuroplasticity, biochemistry, biophysics and genetics.


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Author Biographies

Romulo Rodrigues

Professor of Chemistry – UFU Degree

Samuel Nunes

Master in Animal Biology and Diversity – UniUbe Master

References or Bibliography

TETER, Bruce; ASHFORD, J.Wesson. Neuroplasticity in Alzheimer’s disease. Journal of Neuroscience Research, 2002. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jnr.1044.

LIU, Xiaolei; JIAO, Bin; SHEN, Lu. The Epigenetics of Alzheimer’s disease: Factors and Therapeutic implications. Pubmed, 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283895/.

Epigenética: como você pode modular seus genes? Ilha do Conhecimento, São Paulo, 15 de novembro de 2018. Disponível em: https://ilhadoconhecimento.com.br/epigeneticahttps://ilhadoconhecimento.com.br/epigenetica-como-voce-pode-modular-seus-genes/como-voce-pode-modular-seus-genes/.

VEMURI, Prashanthi; et.al. Effect of Apolipoprotein E on Biomarkers of Amyloid Load and Neuronal Pathology in Alzheimer Disease. Pubmed, 2010. Disponível em:


LIU, Chia-Chen; et.al. Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy. Pubmed, 2013. Disponível em:


TANZI, Rudolph; BERTRAM, Lars. Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective. Cell, 2005. Disponível em: https://www.cell.com/cell/fulltext/S0092-8674(05)00152-

?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS00 92867405001522%3Fshowall%3Dtrue.

GLENNER, George; WONG, Caine. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Science Direct, 1984.

Disponível em: https://www.sciencedirect.com/science/article/abs/pii/0006291X84912099?via%3Dihub .

HOOLI, B.V; et. al. Role of common and rare APP DNA sequence variants in Alzheimer disease. Pubmed, 2012. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/0006291X84912099?via%3Dihub .

BIRD, T.D; et.al. Alzheimer's disease: Choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Annals of Neurology, 1983. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.410140306?sid=nlm%3Apubmed.

LUOTO, Teemu; et.al. Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age. Annals of Neurology, 2009. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ana.21696.

KUMAR, Anil; et.al. Alzheimer Disease. Pubmed, 2021. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK499922/.

O’BRIEN, Richard; WONG, Philip. Amyloid Precursor Protein Processing and Alzheimer’s Disease. Pubmed, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174086/. Acesso em dia: 30 de agosto de 2021.

DE PAULA, Vanessa; GUIMARÃES, Fabiana; FORLENZA, Orestes. Papel da proteína TAU na fisiopatologia da demência frontotemporal. Scielo, 2009. Disponível em: https://www.scielo.br/j/rpc/a/8rY9xx4R3tPsNj7yxT9Y94N/?lang=pt.

DUGGER, Brittany; DICKSON, Dennis. Pathology of Neurodegenerative Diseases.

Pubmed, 2017. Disponível em:


CAMPOS, Carlos; et.al. Treatment of Cognitive Deficits in Alzheimer’s Disease: a Psychopharmacological Review. Psychiatria Dubina, 2016. Disponível em:


SERENIKI, Adriana; VITAL, Maria Aparecida Barbato Frazão. A doença de

Alzheimer: aspectos fisiopatológicos e farmacológicos. Revista de Psiquiatria do Rio Grande do Sul, 2008. Disponível em: download (2)(original).pdf.

VIEIRA, Renata; et.al. Epidemiology of early-onset dementia: a review of literature.

Pubmed, 2013. Disponível em:


REITZ, Christiane; BRAYNE, Carol; MAYEUX, Richard. Epidemiology of Alzheimer Disease. Pubmed, 2011. Disponível em:


PANEGYRES, Peter; CHEN, Huei-Yang. Differences between early and late onset Alzheimer’s Disease. Pubmed, 2013. Disponível em:


ROSSOR, Martin; et.al. The diagnosis of young-onset dementia. Pubmed, 2010.

Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947856/.

QIU, Chengxuan. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Pubmed, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181909/.

GARDNER, Raquel; VALCOUR, Victor; YAFFE, Kristine. Dementia in the oldest old: a multi-factorial and growing public health issue. Pubmed, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706944/.

NICOLELIS, Miguel. O verdadeiro criador de tudo: como o cérebro humano esculpiu o universo como conhecemos hoje. Crítica, 2020.

DOIDGE, Norman. The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity. Westminster: Penguin, 2006

DOIDGE, Norman. O cérebro que se transforma. Rio de Janeiro: Record, 2011.

NIEMEYER, Paulo. No labirinto do cérebro. Rio de Janeiro: Objetiva, 2020.

HARARI, Yuval. Sapiens: uma breve história da humanidade. São Paulo: Companhia das Letras, 2015.



How to Cite

Peixoto, H., Rodrigues, R. ., & Nunes, S. (2023). Lost memory: what’s new in the science of Alzheimer’s disease and how it relates to neuroplasticity, biochemistry, biophysics and genetics. Journal of Student Research, 12(1). https://doi.org/10.47611/jsr.v12i1.1864



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