The Effect of Antipyretics on Antibody Production in Pediatric Patients Post-Vaccination


  • Aashi Vora Webb School of Knoxville



Antibodies, vaccine, antipyretic, Pediatrics


The COVID-19 pandemic and subsequent vaccine administration renewed the question of the potential effect that antipyretics have on antibody levels post-vaccination in pediatric patients. Many patients take antipyretics to reduce side effects and fevers as they have anti-inflammatory properties. We reviewed the literature for studies examining the question of whether the consumption of antipyretics reduced post-vaccination antibody titers. We found that there is a correlation between antipyretics decreasing antibody production in the pediatric population when given prophylactically. However, to confirm these results more in depth studies are required. Our PICO question allowed us to narrow our focus into the pediatric population, antipyretic intervention, and antibody levels. Our results reflect a significant decrease in antibody levels, but antipyretics do not affect clinical efficiency of the vaccines. Our world relies on vaccine technology and it has allowed us to survive pandemics like the COVID 19 outbreak. In order to keep using these innovations safely, more trials must be conducted.


Download data is not yet available.


Metrics Loading ...

References or Bibliography

Bancos, S., Bernard, M. P., Topham, D. J., & Phipps, R. P. (2009). Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cellular immunology, 258(1), 18–28.

Brown, Chase DO; Daly, Sarah DO, FAAFP. Do prophylactic antipyretics reduce the efficacy of vaccinations in children? Evidence-Based Practice: February 2020 - Volume 23 - Issue 2 - p 44-46 doi: 10.1097/EBP.0000000000000629

Chau-Glendinning, H., Baber, B., & Neher, J. O. (2020). Do prophylactic antipyretics reduce vaccination-associated symptoms in children? The Journal of family practice, 69(3), E21–E22.

Chen, J. S., Alfajaro, M. M., Chow, R. D., Wei, J., Filler, R. B., Eisenbarth, S. C., & Wilen, C. B. (2021). Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. Journal of virology, 95(7), e00014-21. Advance online publication.

Culbreth, Marilynn J., Sergei S. Biryukov, Jennifer L. Shoe, Jennifer L. Dankmeyer, Melissa Hunter, Christopher P. Klimko, Raysa Rosario-Acevedo, David P. Fetterer, Alicia M. Moreau, Susan L. Welkos, and Christopher K. Cote. 2019. "The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice" Vaccines 7, no. 4: 205.

Das RR, Panigrahi I, Naik SS (2014) The Effect of Prophylactic Antipyretic Administration on Post-Vaccination Adverse Reactions and Antibody Response in Children: A Systematic Review. PLoS ONE 9(9): e106629. doi:10.1371/journal.pone.0106629

de Martino, M., Chiarugi, A., Boner, A., Montini, G., & De' Angelis, G. L. (2017). Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. Drugs, 77(12), 1295–1311.

Kobashi Y, Shimazu Y, Kawamura T, Nishikawa Y, Omata F, Kaneko Y, et al. (2022) Factors associated with anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein antibody titer and neutralizing activity among healthcare workers following vaccination with the BNT162b2 vaccine. PLoS ONE 17(6): e0269917.

Koufoglou, E., Kourlaba, G. & Michos, A. Effect of prophylactic administration of antipyretics on the immune response to pneumococcal conjugate vaccines in children: a systematic review. Pneumonia 13, 7 (2021).

Kloc, M., Ghobrial, R. M., Kuchar, E., Lewicki, S., & Kubiak, J. Z. (2020). Development of child immunity in the context of COVID-19 pandemic. Clinical immunology (Orlando, Fla.), 217, 108510.

Lafleur, Bonnie J., Lisa White, Michael D. Dake, Janko Nikolich-Zugich, Ryan Sprissler, Deepta Bhattacharya medRxiv 2022.10.14.22281103; doi:

NCI Dictionary of Cancer Terms. (n.d.). National Cancer Institute. Retrieved August 2022,

Ooi, E. E., Dhar, A., Petruschke, R., Locht, C., Buchy, P., & Low, J. (2022). Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination. NPJ vaccines, 7(1), 31.

Park, J.Y.; Choi, S.-H.; Chung, J.-W.; Hwang, M.-H.; Kim, M.-C. Systemic Adverse Events and Use of Antipyretics Predict the Neutralizing Antibody Positivity Early after the First Dose of ChAdOx1 Coronavirus Disease Vaccine. J. Clin. Med. 2021, 10, 2844. 10.3390/jcm10132844

Pulendran, B., & Ahmed, R. (2011). Immunological mechanisms of vaccination. Nature immunology, 12(6), 509–517.

Saleh, E., Moody, M. A., & Walter, E. B. (2016). Effect of antipyretic analgesics on immune responses to vaccination. Human vaccines & immunotherapeutics, 12(9), 2391–2402.

Sil, A., Ravi, M. D., Patnaik, B. N., Dhingra, M. S., Dupuy, M., Gandhi, D. J., Dhaded, S. M., Dubey, A. P., Kundu, R., Lalwani, S. K., Chhatwal, J., Mathew, L. G., Gupta, M., Sharma, S. D., Bavdekar, S. B., Rout, S. P., Jayanth, M. V., D'Cor, N. A., Mangarule, S. A., Ravinuthala, S., … Reddy E, J. (2017). Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants. Vaccine, 35(22), 2999–3006.

Simon, A. K., Hollander, G. A., & McMichael, A. (2015). Evolution of the immune system in humans from infancy to old age. Proceedings. Biological sciences, 282(1821), 20143085.

Skelly, M. M., & Hawkey, C. J. (2002). Potential alternatives to COX 2 inhibitors. BMJ (Clinical research ed.), 324(7349), 1289–1290.

Tani, N., Chong, Y., Kurata, Y., Gondo, K., Oishi, R., Goto, T., Minami, J., Onozawa, K., Nagano, S., Shimono, N., Ikematsu, H., & Kuwano, H. (2022). Relation of fever intensity and antipyretic use with specific antibody response after two doses of the BNT162b2 mRNA vaccine. Vaccine, 40(13), 2062–2067.



How to Cite

Vora, A. (2023). The Effect of Antipyretics on Antibody Production in Pediatric Patients Post-Vaccination. Journal of Student Research, 12(1).



Research Projects