A Novel Approach to the Efficacy of Induced Pluripotent Stem Cells (iPSCs) in Spinal Cord Injury Repair and Motor Function Recover
DOI:
https://doi.org/10.47611/jsrhs.v14i1.8986Keywords:
Spinal Cord Injury (SCI), Induced Pluripotent Stem Cells (iPSCs), neural progenitor cells (NPCs), motor function recovery, regenerative medicineAbstract
Spinal cord injuries (SCI) are a particular frontier for regenerative medicine, both in terms of the complexity of the spinal tissue and the limits of natural repair. Some studies have recently looked at the potential of iPSCs for the repair of SCI because they can divide into cell types such as neurons and glia, which are critical for restoring the spinal cord. This paper aims to assess the therapeutic potential of iPSCs in SCI, specifically their contribution to motor function recovery. In an experimental protocol involving both in vitro cell culture and in vivo SCI, iPSCs were grown, differentiated into neural precursor cells, and transferred to SCI sites. Behavioral and histological markers of motor control and cell integration were also performed. These findings suggest that iPSCs are critical for structural repair and functional restoration of SCI, suggesting their promise as a regenerative therapy. These results highlight the promise of iPSCs in SCI treatment and help to guide future clinical use.
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