Hydrogels & Bone Regeneration in Adults

Chemical Advancements & Orthopedic Implications (2010–2024)

Authors

  • María del Llano Commonwealth-Parkville School
  • Johnny Lopez-Figueroa Commonwealth-Parkville School

DOI:

https://doi.org/10.47611/jsrhs.v14i1.8676

Keywords:

hydrogels, bone regeneration, biomimetic hydrogels, nanoclay-composite hydrogels, injectable hydrogels, osteogenesis, tissue engineering, drug delivery systems, biocompatibility, mechanical strength

Abstract

This study offers a thorough analysis of the potential of hydrogels as a bone regeneration therapy for the elderly. Additionally, it offers a thorough analysis of current research on a range of hydrogel forms, including injectable formulations, nanoclay composites, and biomimetics. The sources thoroughly weigh the benefits and drawbacks of different hydrogels in promoting bone repair, giving special consideration to their biocompatibility, mechanical strength, and drug delivery. The project's ultimate objective is to support the creation of more effective, patient-specific orthopedic medicines grounded on rigorous research.

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Author Biography

Johnny Lopez-Figueroa, Commonwealth-Parkville School

English teacher

Literature teacher

Research Advisor

Apple Learning Coach

Digital Instructional Coach 

References or Bibliography

De Leon-Oliva, D., Boaru, D. L., Perez-Exposito, R. E., Fraile-Martinez, O., García-Montero, C., Diaz, R., Bujan, J., García-Honduvilla, N., Lopez-Gonzalez, L., Álvarez-Mon, M., Saz, J. V., de la Torre, B., & Ortega, M. A. (2023). Advanced hydrogel-based strategies for enhanced bone and cartilage regeneration: A comprehensive review. Gels (Basel, Switzerland), 9(11), 885. https://doi.org/10.3390/gels9110885

Gao, Y., Zhang, X., & Zhou, H. (2023). Biomimetic hydrogel applications and challenges in bone, cartilage, and nerve repair. Pharmaceutics, 15(10), 2405. https://doi.org/10.3390/pharmaceutics15102405

Grosso, A., et al. (2017). Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis. Frontiers in Bioengineering and Biotechnology.

Hwang, H. S., & Lee, C.-S. (2024). Nanoclay-composite hydrogels for bone tissue engineering. Gels, 10(8), 513.

Hwang, H. S., & Lee, C.-S. (2023). Recent progress in hyaluronic-acid-based hydrogels for bone tissue engineering. Gels, 9(7), 588. https://doi.org/10.3390/gels9070588

Liu, X., Sun, S., Wang, N., Kang, R., Xie, L., & Liu, X. (2022). Therapeutic application of hydrogels for bone-related diseases. Frontiers in Bioengineering and Biotechnology, 10, 998988. https://doi.org/10.3389/fbioe.2022.998988

Olov, N., Bagheri-Khoulenjani, S., & Mirzadeh, H. (2022). Injectable hydrogels for bone and cartilage tissue engineering: A review. Progress in Biomaterials, 11(2), 113–135. https://doi.org/10.1007/s40204-022-00185-8

Tang, G., Tan, Z., Zeng, W., Wang, X., Shi, C., Liu, Y., He, H., Chen, R., & Ye, X. (2020). Recent advances of chitosan-based injectable hydrogels for bone and dental tissue regeneration. Frontiers in Bioengineering and Biotechnology, 8, 587658. https://doi.org/10.3389/fbioe.2020.587658

Yue, S., He, H., Li, B., & Hou, T. (2020). Hydrogel as a biomaterial for bone tissue engineering: A review. Nanomaterials, 10(8), 1511. https://doi.org/10.3390/nano10081511

Zhang, Y., Yu, T., Peng, L., Sun, Q., Wei, Y., & Han, B. (2020). Advancements in hydrogel-based drug sustained release systems for bone tissue engineering. Frontiers in Pharmacology, 11, 622. https://doi.org/10.3389/fphar.2020.00622

Published

02-28-2025

How to Cite

del Llano, M., & Lopez-Figueroa, J. . (2025). Hydrogels & Bone Regeneration in Adults: Chemical Advancements & Orthopedic Implications (2010–2024). Journal of Student Research, 14(1). https://doi.org/10.47611/jsrhs.v14i1.8676

Issue

Section

HS Research Projects