Long-Term Neurological Effects of Multiple Concussions in Athletes who perform Contact Sports: The Development of Chronic Traumatic Encephalopathy
DOI:
https://doi.org/10.47611/jsrhs.v13i4.8089Keywords:
Contact Sport Risks, Chronic Traumatic Encephalopathy, Concussions, Biomarkers, Traumatic Brain InjuryAbstract
Contact-sports are often regarded as one of the most dangerous athletic events to participate in, as countless injuries could occur. Traumatic brain injuries (TBI’s) can occur by repeated concussions or severe impacts to the skull in these sports, and can unfortunately lead to various neurodegenerative diseases such as CTE. The accumulation of p-tau from the oxidative stress of these blows to the brain destabilizes neurons and causes the brain to collapse in function. This secondary literature review aims to identify possible diagnostics and treatment options in the early stages of CTE when the patient is still alive. Through solely online sources, the paper, which is focused on neurology, delves in-depth into how radiology, environmental hazards, biomarkers, genetics, aptitude tests, and updated safety equipment and rules can hopefully prevent, diagnose, and treat CTE. These categories presented varied methods in which technology could advance in the future to combat this neurodegenerative disease, such as utilizing cognitive domains from Alzheimer’s and Parkinson’s disease to see parallel patterns in CTE and identify unique ones in cognitive screening exams. Most causes of death of those associated with CTE are suicide and substance abuse, and nobody can know why their behaviors are so different in life after athletics due to CTE only being discovered in autopsies after death. These aforementioned ways could help solve a critical issue many researchers have faced ever since contact-sports were invented.
Keywords: Contact Sport Risks, Chronic Traumatic Encephalopathy, Concussions, Biomarkers, Traumatic Brain Injury
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Cherry, J. D., Mez, J., Crary, J. F., Tripodis, Y., Alvarez, V. E., Mahar, I., Huber, B. R., Alosco, M. L., Nicks, R., Abdolmohammadi, B., Kiernan, P. T., Evers, L., Svirsky, S., Babcock, K., Gardner, H. M., Meng, G., Nowinski, C. J., Martin, B. M., Dwyer, B., … Stein, T. D. (2018). Variation in TMEM106B in chronic traumatic encephalopathy - acta neuropathologica communications. BioMed Central. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0619-9
Cherry, J. D., Stein, T. D., Tripodis, Y., Alvarez, V. E., Huber, B. R., Au, R., Kiernan, P. T., Daneshvar, D. H., Mez, J., Solomon, T. M., Alosco, M. L., & McKee, A. C. (2017). CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PloS one. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614644/
Cleveland Clinic. (2024). Chronic traumatic encephalopathy (CTE): Symptoms & treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/17686-chronic-traumatic-encephalopathy-cte
Daneshvar, D. H., Baugh, C. M., Nowinski, C. J., McKee, A. C., Stern, R. A., & Cantu, R. C. (2011). Helmets and mouthguards: The role of personal equipment in preventing sport-related concussions. Clinics in sports medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987604/
Ehrenberg, A. J., Khatun, A., Coomans, E., Betts, M. J., Capraro, F., Thijssen, E. H., Senkevich, K., Bharucha, T., Jafarpour, M., Young, P. N. E., Jagust, W., Carter, S. F., Lashley, T., Grinberg, L. T., Pereira, J. B., Mattsson-Carlgren, N., Ashton, N. J., Hanrieder, J., Zetterberg, H., … Paterson, R. W. (2020). Relevance of biomarkers across different neurodegenerative diseases. Alzheimer’s research & therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222479/
Ehrenberg, A. J., Khatun, A., Coomans, E., Betts, M. J., Capraro, F., Thijssen, E. H., Senkevich, K., Bharucha, T., Jafarpour, M., Young, P. N. E., Jagust, W., Carter, S. F., Lashley, T., Grinberg, L. T., Pereira, J. B., Mattsson-Carlgren, N., Ashton, N. J., Hanrieder, J., Zetterberg, H., … Paterson, R. W. (2020). Relevance of biomarkers across different neurodegenerative diseases. Alzheimer’s research & therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222479/
Fatsis, S. (2014). Children should not be allowed to head a soccer ball. Slate Magazine. https://slate.com/culture/2014/03/soccer-headers-and-children-why-kids-shouldnt-be-allowed-to-hit-the-ball-with-their-heads.html
Feiss, R., Lutz, M., Reiche, E., Moody, J., & Pangelinan, M. (2020). A systematic review of the effectiveness of concussion education programs for coaches and parents of Youth Athletes. International journal of environmental research and public health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216205/
Halicki, M. J., Hind, K., & Chazot, P. L. (2023). Blood-based biomarkers in the diagnosis of chronic traumatic encephalopathy: Research to date and Future Directions. MDPI. https://www.mdpi.com/1422-0067/24/16/12556
Halicki, M. J., Hind, K., & Chazot, P. L. (2023). Blood-based biomarkers in the diagnosis of chronic traumatic encephalopathy: Research to date and Future Directions. International journal of molecular sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454393/
Holper, S., Watson, R., & Yassi, N. (2022). Tau as a biomarker of neurodegeneration. International journal of molecular sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266883/
McKee, A. (2023). Researchers find CTE in 345 of 376 former NFL players studied. Chobanian Avedisian School of Medicine Researchers Find CTE in 345 of 376 Former NFL Players Studied Comments. https://www.bumc.bu.edu/camed/2023/02/06/researchers-find-cte-in-345-of-376-former-nfl-players-studied/
Nabi, M., & Tabassum, N. (2022). Role of environmental toxicants on Neurodegenerative Disorders. Frontiers in toxicology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131020/
Nakatsuka, A. S., & Yamamoto, L. G. (2014). External foam layers to football helmets reduce head impact severity. Hawai’i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142580/
Omalu BI, Hamilton RL, Kamboh MI, DeKosky ST, Bailes J. Chronic traumatic encephalopathy (CTE) in a National Football League Player: Case report and emerging medicolegal practice questions. J Forensic Nurs. 2010 Spring;6(1):40-6. doi: 10.1111/j.1939-3938.2009.01064.x. PMID: 20201914.
Priemer DS, Iacono D, Rhodes CH, Olsen CH, Perl DP. Chronic Traumatic Encephalopathy in the Brains of Military Personnel. N Engl J Med. 2022 June 9;386(23):2169-2177. doi: 10.1056/NEJMoa2203199. PMID: 35675177.
Quigley, K. G., Hopfe, D., Taylor, M. R., Pavilionis, P., Owusu-Amankonah, V., Islas, A., & Murray, N. G. (2023). Preliminary examination of Guardian CAP head impact data using instrumented mouthguards. ArXiv. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980188/
Rodrigues, A. C., Lasmar, R. P., & Caramelli, P. (2016). Effects of soccer heading on brain structure and function. Frontiers in neurology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800441/
Suter, C. M., Affleck, A. J., Lee, M., Pearce, A. J., Iles, L. E., & Buckland, M. E. (2022). Chronic traumatic encephalopathy in Australia: The first three years of the Australian Sports Brain Bank. The Medical journal of Australia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305557/
Tipton, P. W., Day, G. S., & Graff-Radford, N. (2021). A neurologist’s practical approach to cognitive impairment. Seminars in neurology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697758/
Young, A. B. (2009). Four decades of Neurodegenerative Disease Research: How far we have come!. The Journal of neuroscience : the official journal of the Society for Neuroscience. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807668/
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