The Relationship Between Lipids and Lipoproteins in Spinal Cord Injury: A review

Ahmed S, Shah P, & Ahmed, O. (2023). Biochemistry, lipids. [Updated 2023 May 1]. In StatPearls [Internet]. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK525952/

Ahuja, C. S., & Fehlings, M. (2016). Concise review: Bridging the gap: Novel neuroregenerative and neuroprotective strategies in spinal cord injury. Stem Cells Translational Medicine, 5(7), 914–924. https://doi.org/10.5966/sctm.2015-0381

Ahuja, C. S., Nori, S., Tetreault, L., Wilson, J., Kwon, B., Harrop, J., Choi, D., & Fehlings, M. G. (2017). Traumatic spinal cord injury-repair and regeneration. Neurosurgery, 80(3S), S9–S22. https://doi.org/10.1093/neuros/nyw080

Al-Hussaniy, H. A., Alburghaif, A. H., & Naji, M. A. (2021). Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions. Journal of Medicine and Life, 14(5), 600–605. https://doi.org/10.25122/jml-2021-0153

Alizadeh, A., Dyck, S. M., & Karimi-Abdolrezaee, S. (2019). Traumatic spinal cord injury: An overview of pathophysiology, models and acute injury mechanisms. Frontiers in Neurology, 10, 282. https://doi.org/10.3389/fneur.2019.00282

Bailey, A., & Mohiuddin, S.S. (2022). Biochemistry, high density lipoprotein. [Updated 2022 Sep 26]. In StatPearls [Internet]. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK549802

Bertolio, R., Napoletano, F., Mano, M., Maurer-Stroh, S., Fantuz, M., Zannini, A., Bicciato, S., Sorrentino, G., & Del Sal, G. (2019). Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. Nature Communications, 10, 1326. https://doi.org/10.1038/s41467-019-09152-7

Björkegren, J. L. M., & Lusis, A. J. (2022). Atherosclerosis: Recent developments. Cell, 185(10), 1630–1645. https://doi.org/10.1016/j.cell.2022.04.004

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M. T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., Möbius, W., & Simons, M. (2018). Defective cholesterol clearance limits remyelination in the aged central nervous system. Science, 359(6376), 684–688. https://doi.org/10.1126/science.aan4183

Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D. (2015). Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology. Biochimica et Biophysica Acta, 1851(1), 51–60. https://doi.org/10.1016/j.bbalip.2014.08.011

Cooper, G.M. (2000). The cell: A molecular approach. 2nd edition. Sunderland (MA): Sinauer Associates. The Mechanism of Vesicular Transport. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9886/

Craig, M., Yarrarapu, SNS., & Dimri, M. (2023). Biochemistry, cholesterol. [Updated 2023 Aug 8]. In StatPearls [Internet]. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513326

Desimone, A., Hong, J., Brockie, S. T., Yu, W., Laliberte, A., M., & Fehlings, M. G. (2021). The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy. JCI Insight, 6(15): e149227. https://doi.org/10.1172/jci.insight.149227

Dowhan, W. & Bogdanov, M. (2002). Chapter 1 Functional roles of lipids in membranes. New Comprehensive Biochemistry, 36, 1-35. https://doi.org/10.1016/S0167-7306(02)36003-4

Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000). Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. The Journal of clinical investigation, 105(8), 1049–1056. https://doi.org/10.1172/JCI9259

Feingold, K.R. (2024). Introduction to lipids and lipoproteins. [Updated 2024 Jan 14]. In K.R. Feingold, B. Anawalt, M.R. Blackman, et al., (Eds). Endotext [Internet]. MDText.com, Inc. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305896/

Gilbert, O., Croffoot, J. R., Taylor, A. J., Nash, M., Schomer, K., & Groah, S. (2014). Serum lipid concentrations among persons with spinal cord injury - a systematic review and meta-analysis of the literature. Atherosclerosis, 232(2), 305–312. https://doi.org/10.1016/j.atherosclerosis.2013.11.028

Gorgey, A. S., Mather, K. J., & Gater, D. R. (2011). Central adiposity associations to carbohydrate and lipid metabolism in individuals with complete motor spinal cord injury. Metabolism: Clinical and Experimental, 60(6), 843–851. https://doi.org/10.1016/j.metabol.2010.08.002

de Groot, S., Dallmeijer, A. J., Post, M. W., Angenot, E. L., & van der Woude, L. H. (2008). The longitudinal relationship between lipid profile and physical capacity in persons with a recent spinal cord injury. Spinal Cord, 46(5), 344–351. https://doi.org/10.1038/sj.sc.3102147

Hellenbrand, D. J., Quinn, C. M., Piper, Z. J., Morehouse, C. N., Fixel, J. A., & Hanna, A. S. (2021). Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. Journal of Neuroinflammation, 18(1), 284. https://doi.org/10.1186/s12974-021-02337-2

Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Bei, M., Zhao, J., Zhu, R., & Cheng, L. (2023). Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy, 8, 245. https://doi.org/10.1038/s41392-023-01477-6

Huang, Y., & Mahley, R. W. (2014). Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiology of Disease, 72 Pt A, 3–12. https://doi.org/10.1016/j.nbd.2014.08.025

Juarez Casso, F.M. & Farzam, K. (2022). Biochemistry, very low density lipoprotein. [Updated 2022 Dec 4]. In StatPearls [Internet]. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK587400

Koutsodendris, N., Blumenfeld, J., Agrawal, A., Traglia, M., Grone, B., Zilberter, M., Yip, O., Rao, A., Nelson, M. R., Hao, Y., Thomas, R., Yoon, S. Y., Arriola, P., & Huang, Y. (2023). Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits. Nature Aging, 3(3), 275–296. https://doi.org/10.1038/s43587-023-00368-3

Kwiecien, J. M., Dabrowski, W., Dąbrowska-Bouta, B., Sulkowski, G., Oakden, W., Kwiecien-Delaney,C. J., Yaron, J. R., Zhang, L., Schutz, L., Marzec-Kotarska, L. B., Stanisz, G. J., Karis, J. P., Struzynska, L., & Lucas, A. R. (March 2020). Prolonged inflammation leads to ongoing damage after spinal cord injury. PLOS ONE, 15(3), e0226584 - March 2020. https://doi.org/10.1371/journal.pone.0226584

Lima, R., Monteiro, A., Salgado, A. J., Monteiro, S., & Silva, N. A. (2022). Pathophysiology and therapeutic approaches for spinal cord injury. International Journal of Molecular Sciences, 23(22), 13833. https://doi.org/10.3390/ijms232213833

Mar, F. M., da Silva, T. F., Morgado, M. M., Rodrigues, L. G., Rodrigues, D., Pereira, M. I. L., Marques, A., Sousa, V. F., Coentro, J., Sá-Miranda, C., Sousa, M. M., & Brites, P. (2016). Myelin lipids inhibit axon regeneration following spinal cord injury: A novel perspective for therapy. Molecular Neurobiology, 53(2), 1052–1064. https://doi.org/10.1007/s12035-014-9072-3

Mahley, R. W., Weisgraber, K. H, & Huang, Y. (2006). Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease. Proceedings of the National Academy of Sciences, 103(15) 5644-5651. https://doi.org/10.1073/pnas.060054910

Mayo Foundation for Medical Education and Research (MFMER). (2023). Spinal cord injury. Retrieved from https://www.mayoclinic.org/diseases-conditions/spinal-cord-injury/symptoms-causes/syc-20377890

National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health. (2021). Spinal cord injury: Hope through research, NINDS, Publication date July 2013. NIH Publication 13-NS-160. Retrieved from https://catalog.ninds.nih.gov/sites/default/files/publications/spinal-cord-injury-hope-through-research_0.pdf

Rankin, K. C., O'Brien, L. C., Segal, L., Khan, M. R., & Gorgey, A. S. (2017). Liver adiposity and metabolic profile in individuals with chronic spinal cord injury. BioMed Research International, 2017, 1364818. https://doi.org/10.1155/2017/1364818

Patel, M. B., Oza, N. A., Anand, I. S., Deshpande, S. S., & Patel, C. N. (2008). Liver x receptor: a novel therapeutic target. Indian Journal of Pharmaceutical Sciences, 70(2), 135–144. https://doi.org/10.4103/0250-474X.41445

Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015). Free radicals: Properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry: IJCB, 30(1), 11–26. https://doi.org/10.1007/s12291-014-0446-0

Phillips M. C. (2014). Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB life, 66(9), 616–623. https://doi.org/10.1002/iub.1314

Roselló-Busquets, C., de la Oliva, N., Martínez-Mármol, R., Hernaiz-Llorens, M., Pascual, M., Muhaisen, A., Navarro, X., Del Valle, J., & Soriano, E. (2019). Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration. Frontiers in Cellular Neuroscience, 13, 40. https://doi.org/10.3389/fncel.2019.00040

Roy, D., & Tedeschi, A. (2021). The role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and repair after CNS injury and disease. Cells, 10(5), 1078. https://doi.org/10.3390/cells10051078

Ryan, C. B., Choi, J. S., Al-Ali, H., & Lee, J. K. (2022). Myelin and non-myelin debris contribute to foamy macrophage formation after spinal cord injury. Neurobiology of Disease, 163, 105608. https://doi.org/10.1016/j.nbd.2021.105608

Rukmangadachar, L. A. & Bollu, P. C. (2023). Amyloid beta peptide. [Updated 2023 Aug 28]. In StatPearls [Internet]. StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459119

Strattan, L. E., Britsch, D. R. S., Calulot, C. M., Maggard, R. S. J., Abner, E. L., Johnson, L. A., & Alilain, W. J. (2021). Novel influences of sex and APOE Genotype on spinal plasticity and recovery of function after spinal cord injury. eNeuro, 8(2), ENEURO.0464-20.2021. https://doi.org/10.1523/ENEURO.0464-20.2021

Sterner, R. C., & Sterner, R. M. (2023). Immune response following traumatic spinal cord injury: Pathophysiology and therapies. Frontiers in Immunology, 13, 1084101. https://doi.org/10.3389/fimmu.2022.1084101

Suzuki, A., & Diehl, A. M. (2017). Nonalcoholic steatohepatitis. Annual Review of Medicine, 68, 85–98. https://doi.org/10.1146/annurev-med-051215-031109

Susuki, K. (2010) Myelin: A specialized membrane for cell communication. Nature Education, 3(9), 59. Available at https://www.nature.com/scitable/topicpage/myelin-a-specialized-membrane-for-cell-communication-14367205/

Toro, C. A., Hansen, J., Siddiq, M. M., Johnson, K., Zhao, W., Azulai, D., Das, D. K., Bauman, W., Sebra, R., Cai, D., Iyengar, R., & Cardozo, C. P. (2021). The human ApoE4 variant reduces functional recovery and neuronal sprouting after incomplete spinal cord injury in male mice. Frontiers in Cellular Neuroscience, 15, 626192. https://doi.org/10.3389/fncel.2021.626192

Triplet, E. M., & Scarisbrick, I. A. (2021). Statin use is associated with reduced motor recovery after spinal cord injury. Spinal Cord Series and Cases, 7(1), 8. https://doi.org/10.1038/s41394-020-00378-y

Urano, Y., Ochiai, S., & Noguchi, N. (2013). Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology, 27(10), 4305–4315. https://doi.org/10.1096/fj.13-231456

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J. D., & Holtzman, D. M. (2021). Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron, 109(10), 1657–1674.e7. https://doi.org/10.1016/j.neuron.2021.03.024

Yang, X., Chen, S., Shao, Z., Li, Y., Wu, H., Li, X., Mao, L., Zhou, Z., Bai, L., Mei, X., & Liu, C. (2018). Apolipoprotein E deficiency exacerbates spinal cord injury in mice: Inflammatory response and oxidative stress mediated by NF-κB signaling pathway. Frontiers in Cellular Neuroscience, 12, 142. https://doi.org/10.3389/fncel.2018.00142

Yang, L. G., March, Z. M., Stephenson, R.A., Narayan, P.S. (2023). Apolipoprotein E in lipid metabolism and neurodegenerative disease. Trends in Endocrinology & Metabolism, 34(8). 430 - 445. https://doi.org/10.1016/j.tem.2023.05.002

Yang, C., Wang, X., Wang, J., Wang, X., Chen, W., Lu, N., Siniossoglou, S., Yao, Z., & Liu, K. (2020). Rewiring neuronal glycerolipid metabolism determines the extent of axon regeneration. Neuron, 105(2), 276–292.e5. https://doi.org/10.1016/j.neuron.2019.10.009

Yekutiel, M., Brooks, M. E., Ohry, A., Yarom, J., & Carel, R. (1989). The prevalence of hypertension, ischaemic heart disease and diabetes in traumatic spinal cord injured patients and amputees. Paraplegia, 27(1), 58–62. https://doi.org/10.1038/sc.1989.9

World Health Organization. (2013). Spinal cord injury. Retrieved from https://www.who.int/news-room/fact-sheets/detail/spinal-cord-injury

Zhu, Y., Lyapichev, K., Lee, D. H., Motti, D., Ferraro, N. M., Zhang, Y., Yahn, S., Soderblom, C., Zha, J., Bethea, J. R., Spiller, K. L., Lemmon, V. P., & Lee, J. K. (2017). Macrophage transcriptional profile identifies lipid catabolic pathways that can be therapeutically targeted after spinal cord injury. The Journal of Neuroscience, 37(9), 2362–2376. https://doi.org/10.1523/JNEUROSCI.2751-16.2017