Using Personalized Immunotherapies to Advance Melanoma Treatment
DOI:
https://doi.org/10.47611/jsrhs.v13i3.7462Keywords:
Melanoma, Personalized immunotherapy, Treatment, Immune checkpoint inhibitors, Oncolytic viruses, Tumor-infiltrating lymphocyte therapy, Oncology, Personalized medicineAbstract
Melanoma, a potentially fatal type of skin cancer, presents as a prominent challenge in oncology, due to its significant mortality rates and aggressive nature. This emphasizes the immediate demand for new, effective treatments which address these obstacles, prompting additional research and a concerted effort to quickly find better treatment options. Personalized immunotherapy, which involves tailoring treatments to the unique characteristics of each patient, offers a promising solution. The integration of personalized immunotherapy into treatments both addresses the complexity of the cancer and enhances the effectiveness of therapies. This review underscores how utilizing personalized immunotherapy alongside immune checkpoint inhibitors, oncolytic viruses, and tumor-infiltrating lymphocyte therapy can significantly improve patient outcomes by effectively targeting and eliminating malignant melanoma tumors.
Downloads
References or Bibliography
Abdel-Malek, Z. A., Kadekaro, A. L., & Swope, V. B. (2010). Stepping up melanocytes to the challenge of UV exposure. Pigment Cell & Melanoma Research, 23(2), 171–186. https://doi.org/10.1111/j.1755-148X.2010.00679.x
Andtbacka, R. H. I., Curti, B. D., Kaufman, H., Daniels, G. A., Nemunaitis, J. J., Spitler, L. E., Hallmeyer, S., Lutzky, J., Schultz, S. M., Whitman, E. D., Zhou, K., Karpathy, R., Weisberg, J. I., Grose, M., & Shafren, D. (2015). Final data from CALM: A phase II study of Coxsackievirus A21 (CVA21) oncolytic virus immunotherapy in patients with advanced melanoma. Journal of Clinical Oncology, 33(15_suppl), 9030–9030. https://doi.org/10.1200/jco.2015.33.15_suppl.9030
Antohe, M., Nedelcu, R. I., Nichita, L., Popp, C. G., Cioplea, M., Brinzea, A., Hodorogea, A., Calinescu, A., Balaban, M., Ion, D. A., Diaconu, C., Bleotu, C., Pirici, D., Zurac, S. A., & Turcu, G. (2019). Tumor infiltrating lymphocytes: The regulator of melanoma evolution (Review). Oncology Letters, 17(5), 4155–4161. https://doi.org/10.3892/ol.2019.9940
Au, G., Lindberg, A., Barry, R., & Shafren, D. (2005). Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21. International Journal of Oncology. https://doi.org/10.3892/ijo.26.6.1471
Aurelian, L. (2016). Oncolytic viruses as immunotherapy: Progress and remaining challenges. OncoTargets and Therapy, 9, 2627–2637. https://doi.org/10.2147/OTT.S63049
Bagchi, S., Yuan, R., & Engleman, E. G. (2021). Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance. Annual Review of Pathology: Mechanisms of Disease, 16(1), 223–249. https://doi.org/10.1146/annurev-pathol-042020-042741
Bradley, S., Jakes, A., Harrington, K., Pandha, H., Melcher, A., & Errington-Mais, F. (2014). Applications of coxsackievirus A21 in oncology. Oncolytic Virotherapy, 47. https://doi.org/10.2147/OV.S56322
Brady, J., Kashlan, R., Ruterbusch, J., Farshchian, M., & Moossavi, M. (2021). Racial Disparities in Patients with Melanoma: A Multivariate Survival Analysis. Clinical, Cosmetic and Investigational Dermatology, 14, 547–550. https://doi.org/10.2147/CCID.S311694
Chu, Y., Liu, Q., Wei, J., & Liu, B. (2018). Personalized cancer neoantigen vaccines come of age. Theranostics, 8(15), 4238–4246. https://doi.org/10.7150/thno.24387
De Miguel, M., & Calvo, E. (2020). Clinical Challenges of Immune Checkpoint Inhibitors. Cancer Cell, 38(3), 326–333. https://doi.org/10.1016/j.ccell.2020.07.004
Delhalle, S., Bode, S. F. N., Balling, R., Ollert, M., & He, F. Q. (2018). A roadmap towards personalized immunology. Npj Systems Biology and Applications, 4(1), 1–14. https://doi.org/10.1038/s41540-017-0045-9
Dobosz, P., Stępień, M., Golke, A., & Dzieciątkowski, T. (2022). Challenges of the Immunotherapy: Perspectives and Limitations of the Immune Checkpoint Inhibitor Treatment. International Journal of Molecular Sciences, 23(5), Article 5. https://doi.org/10.3390/ijms23052847
Everts, B., & Poel, H. (2005). Everts, B and van der Poel, HG. Replication-selective oncolytic viruses in the treatment of cancer. Cancer Gene Ther 12: 141-161. Cancer Gene Therapy, 12, 141–161. https://doi.org/10.1038/sj.cgt.7700771
Feldman, S. A., Assadipour, Y., Kriley, I., Goff, S. L., & Rosenberg, S. A. (2015). Adoptive Cell Therapy—Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors. Seminars in Oncology, 42(4), 626–639. https://doi.org/10.1053/j.seminoncol.2015.05.005
Ferrucci, P. F., Pala, L., Conforti, F., & Cocorocchio, E. (2021). Talimogene Laherparepvec (T-VEC): An Intralesional Cancer Immunotherapy for Advanced Melanoma. Cancers, 13(6), Article 6. https://doi.org/10.3390/cancers13061383
Fukuhara, H., Ino, Y., & Todo, T. (2016). Oncolytic virus therapy: A new era of cancer treatment at dawn. Cancer Science, 107(10), 1373–1379. https://doi.org/10.1111/cas.13027
Geukes Foppen, M. H., Donia, M., Svane, I. M., & Haanen, J. B. A. G. (2015). Tumor-infiltrating lymphocytes for the treatment of metastatic cancer. Molecular Oncology, 9(10), 1918–1935. https://doi.org/10.1016/j.molonc.2015.10.018
Goff, S. L., Smith, F. O., Klapper, J. A., Sherry, R., Wunderlich, J. R., Steinberg, S. M., White, D., Rosenberg, S. A., Dudley, M. E., & Yang, J. C. (2010). Tumor Infiltrating Lymphocyte Therapy for Metastatic Melanoma: Analysis of Tumors Resected for TIL. Journal of Immunotherapy, 33(8), 840. https://doi.org/10.1097/CJI.0b013e3181f05b91
Hall, M. S., Teer, J. K., Yu, X., Branthoover, H., Snedal, S., Rodriguez-Valentin, M., Nagle, L., Scott, E., Schachner, B., Innamarato, P., Hall, A. M., Blauvelt, J., Rich, C. J., Richards, A. D., Ceccarelli, J., Langer, T. J., Yoder, S. J., Beatty, M. S., Cox, C. A., … Pilon-Thomas, S. (2023). Neoantigen-specific CD4+ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic melanoma patients. Journal for Immunotherapy of Cancer, 11(10), e007288. https://doi.org/10.1136/jitc-2023-007288
Hamid, O., Robert, C., Daud, A., Hodi, F. S., Hwu, W. J., Kefford, R., Wolchok, J. D., Hersey, P., Joseph, R., Weber, J. S., Dronca, R., Mitchell, T. C., Patnaik, A., Zarour, H. M., Joshua, A. M., Zhao, Q., Jensen, E., Ahsan, S., Ibrahim, N., & Ribas, A. (2019). Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Annals of Oncology, 30(4), 582–588. https://doi.org/10.1093/annonc/mdz011
Hong, J. J., Rosenberg, S. A., Dudley, M. E., Yang, J. C., White, D. E., Butman, J. A., & Sherry, R. M. (2010). Successful Treatment of Melanoma Brain Metastases with Adoptive Cell Therapy. Clinical Cancer Research, 16(19), 4892–4898. https://doi.org/10.1158/1078-0432.CCR-10-1507
Johnson, D. B., Puzanov, I., & Kelley, M. C. (2015). Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma. Immunotherapy, 7(6), 611–619. https://doi.org/10.2217/imt.15.35
Khoja, L., Butler, M. O., Kang, S. P., Ebbinghaus, S., & Joshua, A. M. (2015). Pembrolizumab. Journal for ImmunoTherapy of Cancer, 3(1), 36. https://doi.org/10.1186/s40425-015-0078-9
Kumar, A., Watkins, R., & Vilgelm, A. E. (2021). Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.690499
Kuryk, L., Bertinato, L., Staniszewska, M., Pancer, K., Wieczorek, M., Salmaso, S., Caliceti, P., & Garofalo, M. (2020). From Conventional Therapies to Immunotherapy: Melanoma Treatment in Review. Cancers, 12(10), Article 10. https://doi.org/10.3390/cancers12103057
Lauer, U. M., & Beil, J. (2022). Oncolytic viruses: Challenges and considerations in an evolving clinical landscape. Future Oncology, 18(24), 2713–2732. https://doi.org/10.2217/fon-2022-0440
Lawler, S. E., Speranza, M.-C., Cho, C.-F., & Chiocca, E. A. (2017). Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncology, 3(6), 841–849. https://doi.org/10.1001/jamaoncol.2016.2064
Lee, L., Gupta, M., & Sahasranaman, S. (2016). Immune Checkpoint inhibitors: An introduction to the next-generation cancer immunotherapy. The Journal of Clinical Pharmacology, 56(2), 157–169. https://doi.org/10.1002/jcph.591
Mandal, R., & Chan, T. A. (2016). Personalized Oncology Meets Immunology: The Path Towards Precision Immunotherapy. Cancer Discovery, 6(7), 703–713. https://doi.org/10.1158/2159-8290.CD-16-0146
Mansh, M. (2011). Ipilimumab and Cancer Immunotherapy: A New Hope for Advanced Stage Melanoma. The Yale Journal of Biology and Medicine, 84(4), 381–389.
Mantwill, K., Klein, F. G., Wang, D., Hindupur, S. V., Ehrenfeld, M., Holm, P. S., & Nawroth, R. (2021). Concepts in Oncolytic Adenovirus Therapy. International Journal of Molecular Sciences, 22(19), Article 19. https://doi.org/10.3390/ijms221910522
Marelli, G., Howells, A., Lemoine, N. R., & Wang, Y. (2018). Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.00866
Martin-Liberal, J., Kordbacheh, T., & Larkin, J. (2015). Safety of pembrolizumab for the treatment of melanoma. Expert Opinion on Drug Safety, 14(6), 957–964. https://doi.org/10.1517/14740338.2015.1021774
McCart, J. A., Wang, Z.-H., Xu, H., Hu, Y., Park, B., Alexander, H. R., & Bartlett, D. L. (2002). Development of a Melanoma-Specific Adenovirus. Molecular Therapy, 6(4), 471–480. https://doi.org/10.1006/mthe.2002.0692
Merhavi-Shoham, E., Itzhaki, O., Markel, G., Schachter, J., & Besser, M. (2017). Adoptive Cell Therapy for Metastatic Melanoma. The Cancer Journal, 23, 48–53. https://doi.org/10.1097/PPO.0000000000000240
Merlino, G., Herlyn, M., Fisher, D. E., Bastian, B. C., Flaherty, K. T., Davies, M. A., Wargo, J. A., Curiel-Lewandrowski, C., Weber, M. J., Leachman, S. A., Soengas, M. S., McMahon, M., Harbour, J. W., Swetter, S. M., Aplin, A. E., Atkins, M. B., Bosenberg, M. W., Dummer, R., Gershenwald, J. E., … Ronai, Z. A. (2016). The state of melanoma: Challenges and opportunities. Pigment Cell & Melanoma Research, 29(4), 404–416. https://doi.org/10.1111/pcmr.12475
Moser, J. C., Wei, G., Colonna, S. V., Grossmann, K. F., Patel, S., & Hyngstrom, J. R. (2020). Comparative-effectiveness of pembrolizumab vs. Nivolumab for patients with metastatic melanoma. Acta Oncologica, 59(4), 434–437. https://doi.org/10.1080/0284186X.2020.1712473
Nakajima, H., & Nakatsura, T. (2021). Towards the era of immune checkpoint inhibitors and personalized cancer immunotherapy. Immunological Medicine, 44(1), 10–15. https://doi.org/10.1080/25785826.2020.1785654
Paulson, K. G., Gupta, D., Kim, T. S., Veatch, J. R., Byrd, D. R., Bhatia, S., Wojcik, K., Chapuis, A. G., Thompson, J. A., Madeleine, M. M., & Gardner, J. M. (2020). Age-Specific Incidence of Melanoma in the United States. JAMA Dermatology, 156(1), 57–64. https://doi.org/10.1001/jamadermatol.2019.3353
Reynolds, C. R., Tran, S., Jain, M., & Narendran, A. (2022). Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies. Vaccines, 10(2), Article 2. https://doi.org/10.3390/vaccines10020196
Robert, C., Schadendorf, D., Messina, M., Hodi, F. S., O’Day, S., & for the MDX010-20 investigators. (2013). Efficacy and Safety of Retreatment with Ipilimumab in Patients with Pretreated Advanced Melanoma Who Progressed after Initially Achieving Disease Control. Clinical Cancer Research, 19(8), 2232–2239. https://doi.org/10.1158/1078-0432.CCR-12-3080
Rogiers, A., Boekhout, A., Schwarze, J. K., Awada, G., Blank, C. U., & Neyns, B. (2019). Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors. Journal of Oncology, 2019, e5269062. https://doi.org/10.1155/2019/5269062
Rotte, A., & Bhandaru, M. (2016). Immunotherapy of Melanoma. Springer.
Sankar, K., Ye, J. C., Li, Z., Zheng, L., Song, W., & Hu-Lieskovan, S. (2022). The role of biomarkers in personalized immunotherapy. Biomarker Research, 10(1), 32. https://doi.org/10.1186/s40364-022-00378-0
Stavrakaki, E., Dirven, C. M. F., & Lamfers, M. L. M. (2021). Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response. Cancers, 13(4), Article 4. https://doi.org/10.3390/cancers13040614
Tarhini, A., & Kudchadkar, R. R. (2018). Predictive and on-treatment monitoring biomarkers in advanced melanoma: Moving toward personalized medicine. Cancer Treatment Reviews, 71, 8–18. https://doi.org/10.1016/j.ctrv.2018.09.005
Zablocka, T., Nikolajeva, A., Kreismane, M., Pjanova, D., & Isajevs, S. (2021). Addressing the importance of melanoma tumor infiltrating lymphocytes in disease progression and clinicopathological characteristics. Molecular and Clinical Oncology, 15(6), 1–8. https://doi.org/10.3892/mco.2021.2417
Zhao, Y., Deng, J., Rao, S., Guo, S., Shen, J., Du, F., Wu, X., Chen, Y., Li, M., Chen, M., Li, X., Li, W., Gu, L., Sun, Y., Zhang, Z., Wen, Q., Xiao, Z., & Li, J. (2022). Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges. Cancers, 14(17), Article 17. https://doi.org/10.3390/cancers14174160
Published
How to Cite
Issue
Section
Copyright (c) 2024 Shreya Santhosh; Connor Dunn

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright holder(s) granted JSR a perpetual, non-exclusive license to distriute & display this article.


