Unraveling the Link Between Antibiotics and Cancer Risk: A Literature Review
DOI:
https://doi.org/10.47611/jsrhs.v13i3.7434Keywords:
Oncogenesis, Tumorigenesis, Carcinogenesis, Epidemiology, Microbiome, Chemotherapy, Neoplasms, OncologyAbstract
The relationship between antibiotic use and cancer development has garnered significant attention in recent years, driven by growing concerns about the long-term impacts of antibiotic exposure on human health. This literature review aims to synthesize the existing scientific literature on the potential association between antibiotic use and the risk of developing various types of cancer. Studies have suggested that antibiotics may alter the gut microbiome, leading to dysbiosis, which in turn can influence carcinogenesis through mechanisms such as chronic inflammation, immune system modulation, and changes in metabolic pathways. Additionally, some antibiotics possess direct genotoxic effects that may contribute to cancer risk. This review examines epidemiological studies, observational research, and clinical findings to provide a comprehensive overview of the current understanding of this complex relationship. The evidence indicates a nuanced interaction, with certain antibiotics linked to increased risks for specific cancers, while others show no significant association. The review also highlights gaps in the literature, methodological limitations, and the need for further research to clarify causative pathways and establish more definitive conclusions. Understanding the intricate dynamics between antibiotic use and cancer development is crucial for informing public health policies and guiding the prudent use of antibiotics in clinical practice.
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