Chronic Traumatic Encephalopathy and Its Future in Immunotherapy-Based Treatment
DOI:
https://doi.org/10.47611/jsrhs.v12i4.5862Keywords:
Chronic Traumatic Encephalopathy, CTE, Immunotherapy, Monoclonal-Antibody Therapy, Tau, Tauopathy, Pathogenic Tau, P-tau, Traumatic Brain Injuries, TBIs, mTBI, ConcussionsAbstract
In the annals of medical history, few conditions have captured the world's attention and spurred a race for effective treatments quite like Chronic Traumatic Encephalopathy (CTE). Chronic traumatic encephalopathy (CTE) is a condition rarely studied and is quite a serious neurological disorder that is progressively debilitating. However, the reason why chronic traumatic encephalopathy is rarely studied is because only repeated concussions or traumatic brain injuries (TBIs) can cause CTE. As it so happens to be, many athletes who play close contact sports such as football, hockey, and rugby are at the most risk of developing this disorder. Although there is no definitive way to diagnose CTE during life (it can only be categorized as “probable” CTE), and can only be confirmed postmortem, scientists have identified the criteria and specific potential brain and blood biomarkers associated with CTE such as total tau (t-Tau), phosphorylated tau (p-Tau), neurofilament light chains(NfL), and amyloid-beta (Aβ), etc. These biomarkers could potentially help diagnose CTE while the individual who is suspected to have the disease is living. Furthermore, scientists have been researching immunotherapy, a new potential treatment for CTE. Throughout the following sections, this research article will navigate CTE and its clinical manifestations, pathology, and its implications on individuals and society. Subsequently, this article will discuss immunotherapy, uncovering the fundamental principles that underlie this approach, while highlighting its success in revolutionizing medical treatments for cancer, and the possibility of its future in treating chronic traumatic encephalopathy.
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