Collagen as a Nanonization Strategy for Enhancing Natural Antioxidants in Cancer Treatment
DOI:
https://doi.org/10.47611/jsrhs.v12i4.5675Keywords:
cancer, nanotechnology, collagen, resveratrolAbstract
The purpose of this research was to determine whether nanoscale resveratrol (RSV), collagen added to RSV, is more effective than regular RSV. Collagen is a sturdy emulsifier made in the human body. RSV is an antioxidant which has anti-inflammatory properties, allowing it to reduce reactive oxygen species (ROS) levels, which can induce cancer when in excess. However, RSV is not absorbed easily by the human body since it is excreted easily, making it less effective. This research paper was focused on overcoming the low bioavailability of RSV through reducing particle size. The concept behind this is nanotechnology, using technology to study 1 to 100 nanometer structures. Smaller RSV particles have increased surface area, which dissolves faster in the bloodstream. The hypothesis is that RSV particles would decrease by 8 times the volume, while the ROS levels in 3T3L1 cells would decrease with nanoscale RSV by 50%. The particle size distribution of RSV was measured with a spectrophotometer, while the ROS levels in 3T3L1 cells were measured by ELISA. The collagen-RSV solution had a greater peak than the regular RSV solution, indicating the particle size of RSV decreased after adding collagen. Also, the nanoscale RSV could reduce ROS levels more than regular RSV. This evidence supports the hypothesis that nanoscale RSV is effective in reducing ROS levels, and is smaller than regular RSV.
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