Efficacy of virtual reality treatment with NIBS for Schizophrenia

Authors

  • Sashvathkumar Krishnakumar GIFTED GABBER
  • Jothsna Kethar Gifted Gabber

DOI:

https://doi.org/10.47611/jsrhs.v12i1.4218

Keywords:

schizophrenia, virtual reality, NIBS

Abstract

Technology plays a more significant role in healthcare today than it has ever done before. Technologies such as Artificial Intelligence and neurotechnology have advanced healthcare by leaps and bounds that wouldn’t have even been dreamt about 50 years ago. In recent years, virtual reality technology has advanced along with these technologies and medical professionals have taken an interest in its applications, especially in the treatment of treatment-resistant mental health conditions. Research on whether virtual reality is a viable option for psychotherapy is an ongoing process that is highly influential in the medical world. VR enables therapies that may be more accessible, need less delivery time, and have more ecological validity. While NIBS has the ability to directly modify activity in social brain regions in order to promote neuroplasticity, build neural connections, and improve brain function linked to social cognitive behaviors. This paper will aim to examine the benefits virtual reality along with NIBS (Non-invasive Brain Stimulation) has over today’s conventional treatment method for Schizophrenia through analyzing past case studies and discussing it in the context of a new virtual technology, Metaverse. As a result, it was concluded that virtual reality treatment is a better alternative to standard treatment today. 

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Author Biography

Jothsna Kethar, Gifted Gabber

The 8-week session where the student will conduct research and write a scientific journal guided by Dr.Rajgopal Appavu, Assistant Professor, Vaccine Developer, Senior Data Scientist/Analyst, Toxicologist, and Chemist. After the draft has been approved by Professor, students will be guided to submit their scientific journal.

 

 

 

 

 

 

 

 

 

 

 

References or Bibliography

"Gainsford, K., Fitzgibbon, B., Fitzgerald, P. B., & Hoy, K. E. (2020). Transforming treatments for schizophrenia: Virtual reality, brain stimulation and social cognition. Psychiatry research, 288, 112974."

About tCS - Neuroelectric’s Wiki. (n.d.). https://www.neuroelectrics.com/wiki/index.php/About_tCS

Adery, L.H., Ichinose, M., Torregrossa, L.J., Wade, J., Nichols, H., Bekele, E., Park, S., 2018. The acceptability and feasibility of a novel virtual reality based social skills training game for schizophrenia: Preliminary findings. Psychiatry Research 270, 496–502. https://doi.org/10.1016/j.psychres.2018.10.014.

Bisso, E., Signorelli, M. S., Milazzo, M., Maglia, M., Polosa, R., Aguglia, E., & Caponnetto, P. (2020). Immersive Virtual Reality Applications in Schizophrenia Spectrum Therapy: A Systematic Review. International journal of environmental research and public health, 17(17), 6111. https://doi.org/10.3390/ijerph17176111

Boggio, P., Rêgo, G.G., Marques, L.M., Costa, T.L., 2016. Social psychology and noninvasive electrical stimulation. Journal of European Psychologist 21 (1), 30–40. https://doi.org/10.1027/1016-9040/a000247.

Business Wire. (n.d.). Retrieved November 6, 2022, from https://www.businesswire.com/news/home/20220201006263/en/Epazz-DeskFlex-Will-Launch-Metaverse-Virtual-Clinics-the-Next-Generation-Telemedicine-for-Physicians-and-Health-Care-Facilities

Bütefisch, C.M., Khurana, V., Kopylev, L., Cohen, L.G., 2004. Enhancing Encoding of a Motor Memory in the Primary Motor Cortex By Cortical Stimulation. Journal of

Neurophysiology 91 (5), 2110–2116. https://doi.org/10.1152/jn.01038.2003

Cardoş, R.A., David, O.A., David, D.O., 2017. Virtual reality exposure therapy in flight anxiety: A quantitative meta-analysis. Computers in Human Behavior 72, 371–380. https://doi.org/10.1016/j.chb.2017.03.007.

Complementary Treatments for Schizophrenia. (2018, November 1). WebMD. https://www.webmd.com/schizophrenia/schizophrenia-complementary-treatments

De Carvalho, M., Dias, T., Duchesne, M., Nardi, A., Appolinario, J., 2017. Virtual reality as a promising strategy in the assessment and treatment of bulimia nervosa and binge eating disorder: A systematic review. Behavioral Sciences 7 (4), 43. https://doi.org/ 10.3390/bs7030043.

Dellazizzo, L. (2021, February 12). One-year randomized trial comparing virtual reality-assisted therapy to cognitiveâbehavioral therapy for patients with treatment-resistant schizophrenia. Nature. https://www.nature.com/articles/s41537-021-00139-2?error=cookies_not_supported&code=404dec89-55be-4a53-9f11-fdce00b5183e

Deppermann, S., Notzon, S., Kroczek, A., Rosenbaum, D., Haeussinger, F.B., Diemer, J., Zwanzger, P., 2016. Functional co-activation within the prefrontal cortex supports the maintenance of behavioural performance in fear-relevant situations before an iTBS modulated virtual reality challenge in participants with spider phobia. Behav Brain Res 307, 208–217. https://doi.org/10.1016/j.bbr.2016.03.028.

Florida Behavioral Health. (2019, November 11). What Can Happen if Schizophrenia Goes Untreated. Behavioral Health Florida. https://www.behavioralhealthflorida.com/blog/what-can-happen-if-schizophrenia-goes-untreated/

Glanz, K., Rizzo, A.S., Graap, K., 2003. Virtual reality for psychotherapy: Current reality and future possibilities. Psychotherapy: Theory, Research, Practice, Training 40 (1- 2), 55–67. https://doi.org/10.1037/0033-3204.40.1/2.55.

Green, M.F., Penn, D.L., Bentall, R., Carpenter, W.T., Gaebel, W., Gur, R.C., Heinssen, R.J., 2008. Social cognition in schizophrenia: An NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull 34 (6), 1211–1220. https:// doi.org/10.1093/schbul/sbm145.

Heyse, J., Depreeuw, B., Daele, T. V., Daeseleire, T., Ongenae, F., Backere, F. D., & Turck, F. D. (2022, August 19). An adaptation algorithm for personalised virtual reality exposure therapy. Computer Methods and Programs in Biomedicine. Retrieved November 10, 2022, from https://www.sciencedirect.com/science/article/abs/pii/S0169260722004588#!

Horan, W.P., Green, M.F., 2017. Treatment of social cognition in schizophrenia: Current status and future directions. Journal of Schizophrenia Research 203, 3–11. https:// doi.org/10.1016/j.schres.2017.07.013.

Howell, J. (2022, August 23). Metaverse vs. Virtual Reality: Key Differences. 101 Blockchains. https://101blockchains.com/metaverse-vs-virtual-reality/

Hwang, J. (2019, January 28). The Cutting Edge of Schizophrenia Research: VR as Treatment for Psychosis. Psychiatry Advisor. https://www.psychiatryadvisor.com/home/schizophrenia-advisor/the-cutting-edge-of-schizophrenia-research-vr-as-treatment-for-psychosis/

Kurtz, M.M., Gagen, E., Rocha, N.B.F., Machado, S., Penn, D.L., 2016. Comprehensive treatments for social cognitive deficits in schizophrenia: A critical review and effect-size analysis of controlled studies. Clin Psychol Rev 43, 80–89. https://doi.org/10. 1016/j.cpr.2015.09.003.

Maples-Keller, J.L., Yasinski, C., Manjin, N., Rothbaum, B.O., 2017. Virtual reality-enhanced extinction of phobias and post-traumatic stress. Neurotherapeutics 14 (3), 554–563. https://doi.org/10.1007/s13311-017-0534-y.

Mead, T. (2022, July 15). Fear factor: Study shows virtual reality can cure phobias. 1 News. https://www.1news.co.nz/2022/07/14/fear-factor-study-shows-virtual-reality-can-cure-phobias/

Metaverse Medicine and the Doctor, Patient Avatars Ahead. (2022b, August 12). WebMD. https://www.webmd.com/a-to-z-guides/news/20220812/metaverse-medicine-doctor-patient-avatars-ahead

NHS website. (2021b, November 18). Causes - Schizophrenia. nhs.uk. https://www.nhs.uk/mental-health/conditions/schizophrenia/causes/

Noninvasive Brain Stimulation Program. (n.d.). Mount Sinai Health System. https://www.mountsinai.org/locations/abilities-research-center/programs-technologies/brain-stimulation-program

Orellana, G., & Slachevsky, A. (2013). Executive functioning in schizophrenia. Frontiers in psychiatry, 4, 35. https://doi.org/10.3389/fpsyt.2013.00035

Osoegawa, C., Gomes, J. S., Grigolon, R. B., Brietzke, E., Gadelha, A., Lacerda, A. L. T., Dias, Á. M., Cordeiro, Q., Laranjeira, R., Jesus, D. de, Daskalakis, Z. J., Brunelin, J., Cordes, J., & Trevizol, A. P. (2018, February 4). Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis. Schizophrenia Research. Retrieved November 10, 2022, from https://www.sciencedirect.com/science/article/abs/pii/S0920996418300318#!

Park, C.-B., Choi, J.-S., Park, S.M., Lee, J.-Y., Jung, H.Y., Seol, J.-M., Kwon, J.S., 2014. Comparison of the effectiveness of virtual cue exposure therapy and cognitive behavioral therapy for nicotine dependence. Cyberpsychology, Behavior, and Social Networking 17 (4), 262–267. https://doi.org/10.1089/cyber.2013.0253.

Park, K.M., Ku, J., Choi, S.H., Jang, H.J., Park, J.Y., Kim, S.I., Kim, J.J., 2011. A virtual reality application in role-plays of social skills training for schizophrenia: A randomized, controlled trial. Psychiatry Research 189 (2), 166–172. https://doi.org/10. 1016/j.psychres.2011.04.003.

Psychiatry Online. (n.d.). The American Journal of Psychiatry. Retrieved November 6, 2022, from https://ajp.psychiatryonline.org/action/cookieAbsent

Riva, G., Wiederhold, B.K., Mantovani, F., 2019. Neuroscience of virtual reality: From virtual exposure to embodied medicine. Cyberpsychol Behav Soc Netw 22 (1), 82–96. https://doi.org/10.1089/cyber.2017.29099.gri.

Rossi, S., Hallett, M., Rossini, P.M., Pascual-Leone, A., 2009. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clinical Neurophysiology 120 (12), 2008–2039.

https://doi.org/10.1016/j.clinph.2009.08.016.

Schizophrenia and Your Brain. (2015, December 24). WebMD. https://www.webmd.com/schizophrenia/schizophrenia-and-your-brain

Schizophrenia - Diagnosis and treatment - Mayo Clinic. (2020b, January 7). https://www.mayoclinic.org/diseases-conditions/schizophrenia/diagnosis-treatment/drc-20354449

Schizophrenia - Diagnosis and treatment - Mayo Clinic. (2020c, January 7). https://www.mayoclinic.org/diseases-conditions/schizophrenia/diagnosis-treatment/drc-20354449

Shpancer, N. (2020, March 7). When talking doesn't cure: Negative outcomes in therapy. Psychology Today. Retrieved November 10, 2022, from https://www.psychologytoday.com/us/blog/insight-therapy/202003/when-talking-doesnt-cure-negative-outcomes-in-therapy#:~:text=They%20include%20treatment%20failure%20and,undermining%20of%20self%E2%80%90efficacy.%22

Smith, M.J., Fleming, M.F., Wright, M.A., Roberts, A.G., Humm, L.B., Olsen, D., Bell, M.D., 2015. Virtual reality job interview training and 6-month employment outcomes for individuals with schizophrenia seeking employment. Schizophr Res 166 (1-3), 86–91. https://doi.org/10.1016/j.schres.2015.05.022.

Srivastava, K., Das, R. C., & Chaudhury, S. (2014). Virtual reality applications in Mental Health: Challenges and perspectives. Industrial psychiatry journal. Retrieved November 11, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361984/

Tan, B.L., Lee, S.A., Lee, J., 2018. Social cognitive interventions for people with schizophrenia: A systematic review. Asian J Psychiatr 35, 115–131. https://doi.org/10. 1016/j.ajp.2016.06.013.

Tsang, M.M.Y., Man, D.W.K., 2013. A virtual reality-based vocational training system (VRVTS) for people with schizophrenia in vocational rehabilitation. Schizophr Res 144 (1), 51–62. https://doi.org/10.1016/j.schres.2012.12.024

van 't Wout-Frank, M., Shea, M.T., Larson, V.C., Greenberg, B.D., Philip, N.S., 2019.

Combined transcranial direct current stimulation with virtual reality exposure for

posttraumatic stress disorder: Feasibility and pilot results. Brain Stimul 12 (1), 41–43.

https://doi.org/10.1016/j.brs.2018.09.011.

Vassev, N. (2022, May 25). How the Metaverse Will Reshape Mental Health Therapy. Entrepreneur. https://www.entrepreneur.com/science-technology/how-the-metaverse-will-reshape-mental-health-therapy/427930

What causes schizophrenia? Mind. (n.d.). Retrieved November 10, 2022, from https://www.mind.org.uk/information-support/types-of-mental-health-problems/schizophrenia/causes/

What is Schizophrenia? | NAMI: National Alliance on Mental Illness. (n.d.-b). Retrieved November 6, 2022, from https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Schizophrenia

Your Guide to the Metaverse. (2022, October 25). Ledger. https://www.ledger.com/academy/your-guide-to-the-metaverse

Zheng, C.-J., Liao, W.-J., Xia, W.-G., 2015. Effect of combined low-frequency repetitive transcranial magnetic stimulation and virtual reality training on upper limb function in subacute stroke: a double-blind randomized controlled trail. Journal of Huazhong University of Science and Technology [Medical Sciences] 35 (2), 248–254. https://doi.org/10.1007/s11596-015-1419-0

Published

02-28-2023

How to Cite

Krishnakumar, S., & Kethar, J. (2023). Efficacy of virtual reality treatment with NIBS for Schizophrenia. Journal of Student Research, 12(1). https://doi.org/10.47611/jsrhs.v12i1.4218

Issue

Section

HS Research Articles