Sleep EEG as a Tool for Exploring Mechanisms of Schizophrenia

Authors

  • Seowon Kim Handsworth Secondary School
  • Haykaz Mangardich

DOI:

https://doi.org/10.47611/jsrhs.v11i3.3662

Keywords:

Schizophrenia, neurobiology, EEG, delta, slow-wave, sleep

Abstract

Despite the extensive neuroimaging research investigating the neurodevelopmental mechanisms of schizophrenia, to date we have a limited understanding about how schizophrenia develops. Feinberg’s (1982) popular neurodevelopmental model proposes that excessive synaptic pruning during adolescence as indexed by the loss of delta brain-wave activity (EEG) in non-rapid eye movement (NREM) sleep may underlie the pathophysiology to schizophrenia. Several studies have shown that the amplitude and incidence of delta wave EEG are disrupted in stage 3 sleep in schizophrenia. However, little research has investigated sleep EEG in adolescents who are at high risk for transitioning into psychosis. The current paper reviews recent longitudinal findings documenting the normal rate of delta EEG changes over the childhood and adolescent periods and proposes a sleep EEG study that can help inform how schizophrenia develops in adolescence.

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References or Bibliography

Alvarez-Estevez, D., & Rijsman, R. (2021). Haaglanden Medisch Centrum sleep staging database (version 1.0.0). PhysioNet. https://doi.org/10.13026/gp48-ea60.

Aserinsky, E., & Kleitman, N. (1953). Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science, 118(3062), 273-274. https://doi.org/10.1126/science.118.3062.273

Benson, K. L. (2008). Sleep in schizophrenia. Sleep Medicine Clinics, 3(2), 251-260. https://doi.org/10.1016/j.jsmc.2008.01.001

Caldwell, D. F., & Domino, E. F. (1967). Electroencephalographic and eye movement patterns during sleep in chronic schizophrenic patients. Electroencephalography and Clinical Neurophysiology, 22(5), 414-420. https://doi.org/10.1016/0013-4694(67)90168-X

Califf, R. M. (2018). Biomarker definitions and their applications. Experimental Biology and Medicine, 243(3), 213-221.

Carskadon, M.A., & Dement, W.C. (2011). Monitoring and staging human sleep. In M.H. Kryger, T. Roth, & W.C. Dement (Eds.), Principles and practice of sleep medicine, 5th edition, (pp 16-26). St. Louis: Elsevier Saunders.

Castelnovo, A., Graziano, B., Ferrarelli, F., & D'Agostino, A. (2018). Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives. European Journal of Neuroscience, 48(8), 2738-2758. https://doi.org/10.1111/ejn.13815

Chan, M. S., Chung, K. F., Yung, K. P. & Yeung, W. F. (2017). Sleep in schizophrenia: a systematic review and meta-analysis of polysomnographic findings in case-control studies. Sleep Medicine Reviews, 32, 69–84. https://doi.org/10.1016/j.smrv.2016.03.001

Combrisson, E., Vallat, R., Eichenlaub, J. B., O'Reilly, C., Lajnef, T., Guillot, A., Ruby, P. M., & Jerbi, K. (2017). Sleep: an open-source python software for visualization, analysis, and staging of sleep data. Frontiers in NeuroInformatics, 60. https://doi.org/10.3389/fninf.2017.00060

Dement, W., & Kleitman, N. (1957). Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalography and Clinical Neurophysiology, 9(4), 673-690. https://doi.org/10.1016/0013-4694(57)90088-3

Dement, W. (1955). Dream recall and eye movements during sleep in schizophrenics and normals. Journal of Nervous and Mental Disease, 122, 263–269. https://doi.org/10.1097/00005053-195509000-00007

Fatemi, S. H., & Folsom, T. D. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin, 35(3), 528-548. https://doi.org/10.1093/schbul/sbn187

Feinberg, I. (1982). Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?. Journal of Psychiatric Research, 17(4), 319-334. https://doi.org/10.1016/0022-3956(82)90038-3

Feinberg, I., & Campbell, I. G. (2010). Sleep EEG changes during adolescence: an index of a fundamental brain reorganization. Brain and Cognition, 72(1), 56-65. https://doi.org/10.1016/j.bandc.2009.09.008

Feinberg, I., & Campbell, I. G. (2013). Longitudinal sleep EEG trajectories indicate complex patterns of adolescent brain maturation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 304(4), R296-R303. https://doi.org/10.1152/ajpregu.00422.2012

Feinberg, I., Hibi, S., & Carlson, V. R. (1977). Changes in EEG amplitude during sleep with age. In The Aging Brain and Senile Dementia (pp. 85-98). Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3093-6_6

Feinberg, I., & Hiatt, J. F. (1978). Sleep patterns in schizophrenia: A selective review. Sleep Disorders: Diagnosis and Treatment. New York: Wiley, 205-231.

Feinberg, I., Koresko, R. L., & Gottlieb, F. (1965). Further observations on electrophysiological sleep patterns in schizophrenia. Comprehensive Psychiatry, 6(1), 21-24. https://doi.org/10.1016/S0010-440X(65)80004-9

Feinberg, I., Koresko, R. L., Gottlieb, F., & Wender, P. H. (1964). Sleep electroencephalographic and eye-movement patterns in schizophrenic patients. Comprehensive Psychiatry, 5(1), 44-53. https://doi.org/10.1016/S0010-440X(64)80042-0

Hambrecht, M., Häfner, H., & Löffler, W. (1994). Beginning schizophrenia observed by significant others. Social Psychiatry and Psychiatric Epidemiology, 29(2), 53-60. https://doi.org/10.1007/BF00805621

Heinrichs, D. W., & Carpenter, W. T. (1985). Prospective study of prodromal symptoms in schizophrenic relapse. The American Journal of Psychiatry, 142(3), 371–373. https://doi.org/10.1176/ajp.142.3.371

Hiatt, J. F., Floyd, T. C., Katz, P. H., & Feinberg, I. (1985). Further evidence of abnormal non-rapid-eye-movement sleep in schizophrenia. Archives of General Psychiatry, 42(8), 797-802. https://doi.org/10.1001/archpsyc.1985.01790310059007

Huttenlocher, P. R. (1979). Synaptic density in human frontal cortex-developmental changes and effects of aging. Brain Research, 163(2), 195-205. https://doi.org/10.1016/0006-8993(79)90349-4

Iber, C., Ancoli-Israel, S., Chesson, A. L., and Quan, S. F. (2007). The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Westchester, IL: American Academy of Sleep Medicine.

Insel, T. R. (2010). Rethinking schizophrenia. Nature, 468(7321), 187-193. https://doi.org/10.1038/nature09552

Jaaro-Peled, H., & Sawa, A. (2020). Neurodevelopmental factors in schizophrenia. Psychiatric Clinics, 43(2), 263-274. https://doi.org/10.1016/j.psc.2020.02.010

Johnson, M. B., & Stevens, B. (2018). Pruning hypothesis comes of age. Nature, 554, 438–9.

J.R. Lunsford-Avery, J.M. Orr, T. Gupta, A. Pelletier-Baldelli, D.J. Dean, A.K. Smith Watts, J. Bernard, Z.B. Millman, V.A. Mittal. Sleep dysfunction and thalamic abnormalities in adolescents at ultra-high-risk for psychosis

Kantrowitz, J. T., Oakman, E., Bickel, S., Citrome, L., Spielman, A., Silipo, G., Battaglia, J., & Javitt, D. C. (2010). The importance of a good night's sleep: An open-label trial of the sodium salt of γ-hydroxybutyric acid in insomnia associated with schizophrenia. Schizophrenia Research, 120(1-3), 225–226. https://doi.org/10.1016/j.schres.2010.03.035

Keshavan, M. S., & Tandon, R. (1993). Sleep abnormalities in schizophrenia: pathophysiological significance. Psychological Medicine, 23(4), 831-835. https://doi.org/10.1017/S0033291700026313

Keshavan, M. S., Reynolds, C. F., Miewald, J. M., Montrose, D. M., Sweeney, J. A., Vasko, R. C., & Kupfer, D. J. (1998). Delta sleep deficits in schizophrenia: evidence from automated analyses of sleep data. Archives of General Psychiatry, 55(5), 443-448. https://doi.org/10.1001/archpsyc.55.5.443

Keshavan, M. S. (1999). Development, disease and degeneration in schizophrenia: a unitary pathophysiological model. Journal of Psychiatric Research, 33(6), 513-521. https://doi.org/10.1016/S0022-3956(99)00033-3

Keshavan, M. S., Diwadkar, V. A., Montrose, D. M., Stanley, J. A., & Pettegrew, J. W. (2004). Premorbid characterization in schizophrenia: the Pittsburgh high risk study. World Psychiatry, 3(3), 163-168.

Lunsford-Avery, J. R., & Mittal, V. A. (2013). Sleep dysfunction prior to the onset of schizophrenia: A review and neurodevelopmental diathesis–stress conceptualization. Clinical Psychology: Science and Practice, 20(3), 291-320. https://doi.org/10.1111/cpsp.12041

Manoach, D. S., & Stickgold, R. (2015). Sleep, memory and schizophrenia. Sleep Medicine, 16(5), 553. https://doi.org/10.1016/j.sleep.2015.01.009

McCutcheon, R. A., Marques, T. R., & Howes, O. D. (2020). Schizophrenia—an overview. JAMA Psychiatry, 77(2), 201-210. https://doi.org/10.1001/jamapsychiatry.2019.3360

Monti, J. M., & Monti, D. (2005). Sleep disturbance in schizophrenia. International Review of Psychiatry, 17(4), 247-253. https://doi.org/10.1080/09540260500104516

Rapoport, J. L., Addington, A. M., Frangou, S., Psych M. R. (2015). The neurodevelopmental model of schizophrenia: Update 2005. Molecular Psychiatry, 10, 434–449.

Rechtschaffen A, Kales A, eds. A manual of standardized terminology, techniques and scoring system of sleep stages in human subjects. Los Angeles: Brain Information Service/Brain Research Institute, University of California, 1968.

Saha, S., Chant, D., Welham, J., & McGrath, J. (2005). A systematic review of the prevalence of schizophrenia. PLoS medicine, 2(5), e141. https://doi.org/10.1371/journal.pmed.0020141

Thibaut, F., Boutros, N. N., Jarema, M., Oranje, B., Hasan, A., Daskalakis, Z. J., Wichniak, A., Scmitt, A., Riederer, P., Falkai, P., & Wfsbp Task Force on Biological Markers. (2015). Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part I: Neurophysiology. The World Journal of Biological Psychiatry, 16(5), 280-290. https://doi.org/10.3109/15622975.2015.1050061

Published

08-31-2022

How to Cite

Kim, S., & Mangardich, H. (2022). Sleep EEG as a Tool for Exploring Mechanisms of Schizophrenia. Journal of Student Research, 11(3). https://doi.org/10.47611/jsrhs.v11i3.3662

Issue

Section

HS Research Projects