Identification of Novel Protein Targets for Fenugreek to Treat Diabetes: A Molecular Docking Study

Authors

  • Haasini Nandyala BASIS Independent Silicon Valley, San Jose, CA, 95126
  • Ariel Pham Piedmont Hills High School, San Jose, CA 95132
  • Anushka Wagle Fremont High School, Sunnyvale, CA 94087
  • Hansika Daggolu Mission San Jose High School, Fremont, CA 94539
  • Amrita Guha Alsion Montessori Middle/High School, Fremont, CA 94539
  • Reya Sankar Dougherty Valley High School, San Ramon, CA 94582
  • Chloe Chan Lowell High School, San Francisco, CA 94132
  • Dipti Venkatesh Evergreen Valley High School, San Jose, CA 95148
  • Gayathri Renganathan Aspiring Scholars Directed Research Program, Fremont CA 94538.

DOI:

https://doi.org/10.47611/jsrhs.v10i3.1739

Keywords:

molecular docking, fenugreek, diabetes, drug discovery, protein inhibition

Abstract

Abstract: Trigonella foenum-graecum has been shown to have anti-diabetic potential through a wide variety of in-vivo assays as well as by inhibiting enzymes such as alpha-glucosidase and alpha-amylase. Studies have indicated the therapeutic potential of different phytoconstituents found in Trigonella foenum-graceum including diosgenin trigonelline, 4-hydroxyisoleucine, leucine, and L-lysine. This study aims to find novel protein targets that these specific phytoconstituents from fenugreek can bind to, thereby helping to treat diabetes mellitus. Through multiple stages of molecular docking and analyzing the binding sites in comparison to previously reported inhibitors, a suitable and novel target protein for four of the compounds was found and the relevance to diabetes was discussed, setting up these compounds as novel inhibitors for the target proteins.

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Published

10-10-2021

How to Cite

Nandyala, H., Pham , A. ., Wagle, A., Daggolu, H. ., Guha , A. ., Sankar , R. ., Chan, C. ., Venkatesh , D. ., & Renganathan, G. (2021). Identification of Novel Protein Targets for Fenugreek to Treat Diabetes: A Molecular Docking Study. Journal of Student Research, 10(3). https://doi.org/10.47611/jsrhs.v10i3.1739

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Section

HS Research Articles