Anticancer Potential Of Cephalotaxine and Derivatives as an Alternative for Invasive Therapies

Authors

  • Evangelina Kalathoti Mission San Jose High School
  • Heer Nanda Amador Valley High School
  • Riya Parekh Irvington High School
  • Aditi Shankar Mission San Jose High School
  • Shrimayi Chaganti Monta Vista High School
  • Prachi Heda Dougherty Valley High School
  • Gayathri Renganathan Anna University

DOI:

https://doi.org/10.47611/jsrhs.v10i2.1483

Keywords:

Cephalotaxine (CET), Cephalotaxus Harringtonia, Homoharringtonine (HHT)/Omacetaxine mepesuccinate, JAK2-STAT, PI3K/AKT, MAPK/EKR1/2 Pathways.

Abstract

Cancer is identified by the abnormal accumulation of rapidly dividing cells, serving as the collective term for a multitude of similar conditions categorized through cell growth and proliferation. The disease continues to lead death tolls worldwide and extends to communities across the board in terms of socioeconomic status.(^1) From 1991 to 2017, experts recorded a slight drop in cancer death rates, which can be accredited to an influx of scientific advancements within the past decade that allowed for the implementation of targeted therapy.(^1) In preclinical research, this therapy implies the conjugation of independent drugs retaining anti-carcinogenic properties. The current state of cancer pathology is observed to be non-specific and is, oftentimes, taxing on the patient, proving the need for localized treatment and more efficient drugs. This article analyzes the effectiveness of one compound under the harringtonine alkaloid family, cephalotaxine (CET).(^27) In this work, our team examines the biochemical profile of CET and congener homoharringtonine to hypothesize cephalotaxine’s efficacy as an alternative to invasive cancer therapy.

Downloads

Download data is not yet available.

References or Bibliography

Siegel, R.L., Miller, K.D. and Jemal, A. (2020), Cancer statistics, 2020. CA A Cancer J Clin, 70: 7-30. https://doi.org/10.3322/caac.21590

Seca, A. M. L. (2018, January 16). Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application. PubMed. https://pubmed.ncbi.nlm.nih.gov/29337925/

Cephalotaxine - an overview | ScienceDirect Topics. (1998). ScienceDirect. https://www.sciencedirect.com/topics/neuroscience/cephalotaxine

Lai ZZ, Ho YJ, Lu JW. Cephalotaxine inhibits Zika infection by impeding viral replication and stability. Biochemical and Biophysical Research Communications. 2020 Feb;522(4):1052-1058. DOI: 10.1016/j.bbrc.2019.12.012.

Biosynthesis. (n.d.). Google Books. https://books.google.nl/books?id=fnIoDwAAQBAJ&pg=PA142&lpg=PA142&dq=cephalotaxine+biosynthesis&source=bl&ots=2HlJoX2i2m&sig=ACfU3U3IQFJbYk8kC06XNwufgCR7jAD2XA&hl=en&sa=X&redir_esc=y#v=onepage&q=cephalotaxine%20biosynthesis&f=false

Gandhi, V. G., Plunkett, W. P., & Cortes, J. C. (2014, February 5). Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048124/

Winer, E. S., & DeAngelo, D. J. (2018, March 15). A Review of Omacetaxine: A Chronic Myeloid Leukemia Treatment Resurrected. Oncology and Therapy. https://link.springer.com/article/10.1007/s40487-018-0058-6?error=cookies_not_supported&code=a33353a8-94e1-4b91-9e74-9878373c091e

Choy, K. T., Wong, A. Y., Kaewpreedee, P., Sia, S. F., Chen, D., Hui, K., Chu, D., Chan, M., Cheung, P. P., Huang, X., Peiris, M., & Yen, H. L. (2020). Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral research, 178, 104786. https://doi.org/10.1016/j.antiviral.2020.104786

Wang, Y. W., & Li, W. L. (2003, June 16). A Novel and Efficient Total Synthesis of Cephalotaxine. http://www.paper.edu.cn/scholar/showpdf/MUT2ANyIMTz0Mx0h

National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 65305, Cephalotaxine. Retrieved December 30, 2020 from

Efferth, T., Sauerbrey, A., Halatsch, M., Ross, D. D., & Gebhart, E. (2003, January 1). Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn-Schmiedeberg’s Archives of Pharmacology. https://link.springer.com/article/10.1007/s00210-002-0632-0?error=cookies_not_supported&code=cc30da22-977e-4404-9805-85793d88218c

Pérard-Viret J, Quteishat L, Alsalim R, Royer J, Dumas F. Cephalotaxus Alkaloids. The Alkaloids. Chemistry and Biology. 2017;78:205-352. DOI: 10.1016/bs.alkal.2017.07.001.

American Cancer Society. Cancer Facts & Figures 2020. Atlanta: American Cancer Society; 2020.https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2020.html

Arem, H., & Loftfield, E. (2017). Cancer Epidemiology: A Survey of Modifiable Risk Factors for Prevention and Survivorship. American journal of lifestyle medicine, 12(3), 200–210. https://doi.org/10.1177/1559827617700600

U.S. Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.

Nazario, A., Macheledt, J., & Vogel, V. (1995, March 31). Epidemiology of Cancer and Prevention Strategies. Retrieved December 30, 2020, from https://www.cancernetwork.com/view/epidemiology-cancer-and-prevention-strategies

How Chemotherapy Drugs Work. (2019). Retrieved December 30, 2020, from https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/how-chemotherapy-drugs-work.html

Vasudevan, Damodaran & S, Sreekumari & Vaidyanathan, Kannan. (2017). Chapter-48 Biochemistry of Cancer. 10.5005/jp/books/13014_49.

Isoldi, Mauro & Visconti, Maria & Castrucci, Ana. (2005). Anti-Cancer Drugs: Molecular Mechanisms of Action. Mini reviews in medicinal chemistry. 5. 685-95. 10.2174/1389557054368781.

Tong, Hongyan & Ren, Yanling & Zhang, Fengjuan & Jin, Jie. (2008). Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. European journal of haematology. 81. 259-66. 10.1111/j.1600-0609.2008.01116.x.

Legha SS, Keating M, Picket S, et al. Phase I clinical investigation of homoharringtonine. Cancer Treatment Reports. 1984 Sep;68(9):1085-1091.

Quintás‐Cardama, A., Kantarjian, H. and Cortes, J. (2009), Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009. Cancer, 115: 5382-5393. https://doi.org/10.1002/cncr.24601

Powell, R., Weisleder, D., & Smith, C. (1972). Antitumor Alkaloids from Cephalotaxus harringtonia: Structure and Activity. Journal of Pharmaceutical Sciences, 61(8), 1227-1230. doi:10.1002/jps.2600610812

Chang, Y., Meng, F., Wang, R., Wang, C., Lu, X., & Zhang, Q. (2017). Chemistry, Bioactivity, and the Structure-Activity Relationship of Cephalotaxine-Type Alkaloids From Cephalotaxus sp. Studies in Natural Products Chemistry, 53, 339-373. doi:10.1016/b978-0-444-63930-1.00010-

Lu, K., Savaraj, N., Feun, L. G., Zhengang, G., Umsawasdi, T., & Loo, T. L. (1988, April 1). Pharmacokinetics of homoharringtonine in dogs. Cancer Chemotherapy and Pharmacology. https://link.springer.com/article/10.1007/BF00257360?error=cookies_not_supported&code=2c67adc0-4fc9-4fdc-a16d-b25d173db6a8

Efferth, T., Sauerbrey, A., Halatsch, M., Ross, D. D., & Gebhart, E. (2003b, January 1). Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn-Schmiedeberg’s Archives of Pharmacology. https://link.springer.com/article/10.1007/s00210-002-0632-0?error=cookies_not_supported&code=a7ed3ec5-c6dc-4080-9d8b-d8331c0ab999

J, P., L, Q., R, A., J, R., & F, D. (2017, August 16). Cephalotaxus Alkaloids. Abstract - Europe PMC. http://europepmc.org/article/MED/28838429#s0380

P. (n.d.). Cephalotaxine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Cephalotaxine#section=Toxicity

Simon, S. (2020, January 8). Facts & Figures 2020 Reports Largest One-year Drop in Cancer Mortality. American Cancer Society. https://www.cancer.org/latest-news/facts-and-figures-2020.html

Total Synthesis of (-)-Cephalotaxine. (n.d.). Retrieved January 14, 2021, from https://pubs.acs.org/doi/10.1021/jo00106a023

Shi, X., Zhu, M., Gong, Z., Yang, T., Yu, R., Wang, J., & Zhang, Y. (2019, November 11). Homoharringtonine suppresses LoVo cell growth by inhibiting EphB4 and the PI3K/AKT and MAPK/EKR1/2 signaling pathways. Retrieved January 14, 2021, from https://www.sciencedirect.com/science/article/abs/pii/S0278691519307501#

Published

07-01-2021

How to Cite

Kalathoti, E., Nanda, H., Parekh, R., Shankar, A., Chaganti, S., Heda, P., & Renganathan, G. (2021). Anticancer Potential Of Cephalotaxine and Derivatives as an Alternative for Invasive Therapies. Journal of Student Research, 10(2). https://doi.org/10.47611/jsrhs.v10i2.1483

Issue

Section

HS Review Articles